Beyond the Numbers: Charting Chemical Reaction Space Paul M. Murray, Simon N. G. Tyler, and Jonathan D. Moseley Org. Process Res. Dev. ASAP
Fragment-based lead discovery grows up - News and Analysis Monya Baker NATURE REVIEWS, DRUG DISCOVERY, VOLUME 12, JANUARY 2013, page 5
Fragment-based hit identification: thinking in 3D Andrew D. Morley, Angelo Pugliese, Kristian Birchall, Justin Bower, Paul Brennan, Nathan Brown, Tim Chapman, Martin Drysdale, Ian H. Gilbert, Swen Hoelder, Allan Jordan, Steven V. Ley, Andy Merritt, David Miller, Martin E. Swarbrick, Paul G. Wyatt. Drug Discovery Today, asap. The identification of high-quality hits during the early phases of drug discovery is essential if projects are to have a realistic chance of progressing into clinical development and delivering marketed drugs. As the pharmaceutical industry goes through unprecedented change, there are increasing opportunities to collaborate via pre-competitive networks to marshal multifunctional resources and knowledge to drive impactful, innovative science. The 3D Fragment Consortium is developing fragment-screening libraries with enhanced 3D characteristics and evaluating their effect on the quality of fragment-based hit identification (FBHI) projects.


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Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry Nadin, Alan; Hattotuwagama, Channa; Churcher, Ian, Angewandte Chemie, International Edition (2012), 51(5), 1114-1122
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Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring Brodmann, Tobias; Koos, Peter; Metzger, Albrecht; Knochel, Paul; Ley, Steven V., Organic Process Research & Development, No. 16 (May 18, 2012), pp. 1102 - 1113
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